5/24/2023 0 Comments Diazepam od antidote![]() ![]() Diazepam/naloxone combination completely abolished seizures, significantly improved rat ventilation by reducing inspiratory time ( p < .05) but did not worsen sedation. Diazepam abolished seizures but significantly deepened rat sedation ( p < .05) without improving ventilation. Results: Naloxone reversed tramadol-induced respiratory depression ( p < .05) but significantly increased seizures ( p < .01) and prolonged their occurrence time. Sedation depth, temperature, number of seizures, and intensity, whole-body plethysmography parameters and electroencephalography activity were measured. Materials and methods: Sprague–Dawley rats overdosed with 75 mg/kg intraperitoneal (IP) tramadol were randomized into four groups to receive solvent (control group), diazepam (1.77 mg/kg IP), naloxone (2 mg/kg intravenous bolus followed by 4 mg/kg/h infusion), and diazepam/naloxone combination. ![]() Objective: To investigate the most efficient antidote to reverse tramadol-induced seizures and respiratory depression in overdose. ![]() Tramadol overdose results not only in central nervous system (CNS) depression attributed to its opioid properties but also in seizures, possibly related to non-opioidergic pathways, thus questioning the efficiency of naloxone to reverse tramadol-induced CNS toxicity. Context: Since the banning of dextropropoxyphene from the market, overdoses, and fatalities attributed to tramadol, a WHO step-2 opioid analgesic, have increased markedly. ![]()
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